Vanier Parkway is closed between Beechwood Avenue and Deschamps Avenue after a crash which left a pick-up truck on its side and two men with serious injuries.
The incident happened at 2:19 p.m., Wednesday.
Two men in their 20's needed to be extricated from the truck. They were stabilized by paramedics and taken to Ottawa's trauma centre with multiple injuries.
There is no estimate on when the road may reopen.
We will update this story with the latest information as it becomes available.